18N; Methusalem grants, BOF09 01M00709 and BOF16 MET_V 007, grants from Ghent University Multidisciplinary Research Partnerships, GROUP ID consortium, the Foundation against Cancer F94 2012 188 and FAF F 2016 865, and VIB priligy farmacias del ahorro Minor 1 fludrocortisone will decrease the level or effect of zonisamide by affecting hepatic intestinal enzyme CYP3A4 metabolism